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The best setup for Vasa Nistirio in OSRS is ranged with a Twisted bow, which does 11.35 DPS with a max hit of 80 and 85.0% accuracy at level-99 stats. The full best-in-slot gear, prayer and potion for every combat style are listed below.
The highest-DPS melee, ranged and magic loadouts against Vasa Nistirio, computed with wiki-accurate combat math at maxed (99) stats. Open any setup in the calculator to swap in the gear you own.
Twisted bow
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Masori mask (f)
Dizana's quiver
Necklace of rupture
Seeking dragon arrowTwisted bow.png)
Masori body (f).png)
Masori chaps (f)
Zaryte vambraces.png)
Avernic treads (max)
Venator ring
Scythe of vitur
Inquisitor's great helm
Infernal cape
Amulet of rancour
Rada's blessing 4Scythe of vitur
Inquisitor's hauberk
Inquisitor's plateskirt
Ferocious glovesAvernic treads (max)
Ultor ring
Tumeken's shadow
Ancestral hat
Imbued guthix cape
Occult necklaceRada's blessing 4Tumeken's shadow
Ancestral robe top
Ancestral robe bottom
Confliction gauntlets.png)
Avernic treads (et)
Magus ringAssumes level-99 combat stats and the best relevant prayer and potion, off Slayer task (no Slayer-helmet bonus). DPS is single-target on the boss's base stats; magic setups consider powered staves. Numbers come from RuneBuddy's WASM combat engine, the same one behind the DPS calculator.