Twisted bow
Void ranger helm
Dizana's quiver
Necklace of rupture
Seeking dragon arrow
Twisted bow
Elite void top
Elite void robe
Void knight gloves
Avernic treads (max)
Venator ring
Beta
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Open the Calculator
Dagannoth Prime takes about 24.1 seconds per kill in OSRS with the best setup, a Twisted bow doing 11.79 DPS at level-99 stats. RuneBuddy's Boss Fight Simulator runs the real phased fight tick by tick, so you get a kill-time spread for your own gear rather than a flat DPS number.
Dagannoth Prime has a scripted fight in RuneBuddy's Boss Fight Simulator: its phases, attack rotation and punish mechanics are modelled tick by tick, so kill time accounts for the downtime a flat DPS figure hides. Open any loadout below to run the fight, or see the best-in-slot gear for Dagannoth Prime.
Twisted bow
Void ranger helm
Dizana's quiver
Necklace of rupture
Seeking dragon arrow
Twisted bow
Elite void top
Elite void robe
Void knight gloves
Avernic treads (max)
Venator ring
Tumeken's shadow
Ancestral hat
Imbued guthix cape
Occult necklace
Rada's blessing 4
Tumeken's shadow
Ancestral robe top
Ancestral robe bottom
Confliction gauntlets
Avernic treads (et)
Magus ring
Scythe of vitur
Oathplate helm
Infernal cape
Amulet of rancour
Rada's blessing 4
Scythe of vitur
Oathplate chest
Oathplate legs
Ferocious gloves
Avernic treads (max)
Bellator ringAssumes level-99 combat stats and the best relevant prayer and potion, off Slayer task (no Slayer-helmet bonus). DPS is single-target on the boss's base stats; magic setups consider powered staves. Numbers come from RuneBuddy's WASM combat engine, the same one behind the DPS calculator.