Tumeken's shadow
Ancestral hat
Imbued guthix cape
Occult necklace
Rada's blessing 4
Tumeken's shadow
Ancestral robe top
Ancestral robe bottom
Confliction gauntlets
Avernic treads (et)
Magus ring
Beta
All bosses
Open the Calculator
Barrows - Guthan the Infested takes about 10.5 seconds per kill in OSRS with the best setup, a Tumeken's shadow doing 11.64 DPS at level-99 stats. RuneBuddy's Boss Fight Simulator runs the real phased fight tick by tick, so you get a kill-time spread for your own gear rather than a flat DPS number.
Barrows - Guthan the Infested has a scripted fight in RuneBuddy's Boss Fight Simulator: its phases, attack rotation and punish mechanics are modelled tick by tick, so kill time accounts for the downtime a flat DPS figure hides. Open any loadout below to run the fight, or see the best-in-slot gear for Barrows - Guthan the Infested.
Tumeken's shadow
Ancestral hat
Imbued guthix cape
Occult necklace
Rada's blessing 4
Tumeken's shadow
Ancestral robe top
Ancestral robe bottom
Confliction gauntlets
Avernic treads (et)
Magus ring
Soulreaper axe
Oathplate helm
Infernal cape
Amulet of rancour
Rada's blessing 4
Soulreaper axe
Oathplate chest
Oathplate legs
Ferocious gloves
Avernic treads (max)
Bellator ring
Bow of faerdhinen
Crystal helm
Dizana's quiver
Necklace of rupture
Bow of faerdhinen
Crystal body
Crystal legs
Zaryte vambraces
Avernic treads (max)
Venator ringAssumes level-99 combat stats and the best relevant prayer and potion, off Slayer task (no Slayer-helmet bonus). DPS is single-target on the boss's base stats; magic setups consider powered staves. Numbers come from RuneBuddy's WASM combat engine, the same one behind the DPS calculator.